https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Comparing genotyping algorithms for Illumina's Infinium whole-genome SNP BeadChips https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:13673 Wed 11 Apr 2018 15:24:43 AEST ]]> MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:9567 Wed 11 Apr 2018 15:22:37 AEST ]]> A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:9503 Wed 11 Apr 2018 13:47:54 AEST ]]> A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:13675 Wed 11 Apr 2018 13:42:55 AEST ]]> The complex genetics of multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:13635 Wed 11 Apr 2018 13:35:28 AEST ]]> Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20 https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:7518 Sat 24 Mar 2018 08:38:28 AEDT ]]> Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:13695 1. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals2,3, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk4. Modestly powered genome-wide association studies (GWAS)5-10 have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility11. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis.]]> Sat 24 Mar 2018 08:19:55 AEDT ]]> Common genetic variants in the plasminogen activation pathway are not associated with multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:19188 Sat 24 Mar 2018 07:55:01 AEDT ]]> Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple sclerosis: possible pathomechanism of matrix metalloproteinase activation https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:19980 Sat 24 Mar 2018 07:50:58 AEDT ]]> Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:25354 Sat 24 Mar 2018 07:24:42 AEDT ]]> Potential association of vitamin D receptor polymorphism Taq1 with multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:22288 Sat 24 Mar 2018 07:17:30 AEDT ]]>